*: indicates corresponding authorship. #: indicates equal contribution.
2023
Su N, Villicana C, Zhang C, Lee J, Sinha S, Yang A, Yang F. Aspirin synergizes with mineral particle-coated macroporous scaffolds for bone regeneration through immunomodulation. Theranostics. 2023 Aug 15;13(13):4512-4525. doi: 10.7150/thno.85946. PMID: 37649612 | Article
González Díaz EC, Tai M, Monette CEF, Wu JY, Yang F. “Spatially patterned 3D model mimics key features of cancer metastasis to bone”. Biomaterials. 2023 Aug;299:122163. doi: 10.1016 j.biomaterials.2023.122163. PMID: 37236137. | Article
Roth JG, Brunel LG, Huang MS, Liu Y, Cai B, Sinha S, Yang F, Pașca SP, Shin S, Heilshorn SC. “Spatially controlled construction of assembloids using bioprinting”. Nat Commun. 2023 Jul 19;14(1):4346. doi: 10.1038/s41467-023-40006-5. PMID: 37468483 | Article
“Del1 is a growth factor for skeletal progenitor cells in the fracture Callus”. Sun Y, Boyko T, Marecic O, Struck D, Mann RK, Andrew TW, Lopez M, Tong X, Goodman SB, Yang F, Longaker MT, Chan CKF, Yang GP. Biomolecules, 2023 Aug 3;13(8):1214. doi: 10.3390/biom13081214. PMID: 37627279, PMID: 10452420 | Article
Su N, Villicana C, Barati D, Freeman P, Luo Y, Yang F. Stem Cell Membrane-Coated Microribbon Scaffolds Induce Regenerative Innate and Adaptive Immune Responses in a Critical-Size Cranial Bone Defect Model. Adv Mater. 2023 Mar;35(10):e2208781. doi: 10.1002/adma.202208781. Epub 2023 Jan 11 PMID: 36560890 https://pubmed.ncbi.nlm.nih.gov/36560890/ | Article
Sinha S, Ayushman M, Tong X, Yang F. Dynamically Crosslinked Poly(ethylene-glycol) Hydrogels Reveal a Critical Role of Viscoelasticity in Modulating Glioblastoma Fates and Drug Responses in 3D. Adv Healthc Mater. 2023 Jan;12(1):e2202147. doi:
10.1002/adhm.202202147. PMID: 36239185 https://pubmed.ncbi.nlm.nih.gov/36239185/ | Article
Zhu D, Trinh P, Liu E, Yang F. Cell–Cell Interactions Enhance Cartilage Zonal Development in 3D Gradient Hydrogels. ACS Biomater. Sci. Eng. 2023, 9, 2, 831–843 2023 Jan. https://doi.org/10.1021/acsbiomaterials.2c00469 | Article
2022
Andrew TW, Koepke LS, Wang Y, Lopez M, Steininger H, Struck D, Boyko T, Ambrosi TH, Tong X, Sun Y, Gulati GS, Murphy MP, Marecic O, Telvin R, Schallmoser K, Strunk D, Seita J, Goodman SB, Yang F, Longaker MT, Yang GP, Chan CKF Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration. Nat Commun. 2022 Oct 30;13(1):6491. doi: 10.1038/s41467-022-34063-5.PMID: 36310174 https://pubmed.ncbi.nlm.nih.gov/36310174/ | Article
Conrad B, Yang F. Hydroxyapatite-coated gelatin microribbon scaffolds induce rapid endogenous cranial bone regeneration in vivo. Biomater Adv. 2022 Sep;140:213050. doi: 10.1016/j.bioadv.2022.213050. Epub 2022 Jul 28.PMID: 35917686 | Article
Stanton AE, Tong X, Jing S, Behn AW, Storaci H, Yang F. Aligned microribbon scaffolds with hydroxyapatite gradient for engineering bone-tendon interface. Tissue Eng Part A, 2022 Aug;28(15-16):712-723. doi: 10.1089/ten.TEA.2021.0099. PMID: 35229651 https://pubmed.ncbi.nlm.nih.gov/35229651/ | Article
Huang EE, Zhang N, Ganjo EA, Shen HS, Li X, Ueno M, Utsunomiya T, Maruyama M, Gao Q, Ni S, Yao Z, Yang F, Gaudillière B, Goodman SB. Differential dynamics of bone graft transplantation and mesenchymal stem cell therapy during bone defect healing in a
murine critical size defect, J Orthop Translat. 2022 Aug 4;36:64-74. https://pubmed.ncbi.nlm.nih.gov/35979174/ | Article
Su N, Villicana C, Yang F. Immunomodulatory strategies for bone regeneration: A review from the perspective of disease types. Biomaterials. 2022 Jul;286:121604. doi: 10.1016/j.biomaterials.2022.121604. PMID: 35667249 https://pubmed.ncbi.nlm.nih.gov/35667249/ | Article
González Díaz EC, Lee AG, Sayles LC, Feria C, Sweet-Cordero EA, Yang F. A 3D Osteosarcoma Model with Bone-Mimicking Cues Reveals a Critical Role of Bone Mineral and Informs Drug Discovery. Adv Healthc Mater. 2022 Jun 29:e2200768. doi:
10.1002/adhm.202200768. PMID: 35767377 https://onlinelibrary.wiley.com/doi/10.1002/adhm.202200768 | Article
Hirata H, Zhang N, Ueno M, Barati D, Kushioka J, Shen H, Tsubosaka M, Toya M, Lin T, Huang E, Yao Z, Wu JY, Zwingenberger S, Yang F, Goodman SB. Ageing attenuates bone healing by mesenchymal stem cells in a microribbon hydrogel with a murine long
bone critical-size defect model. Immun Ageing. 2022 Mar 12;19(1):14. doi:10.1186/s12979-022-00272-1. PMID: 35279175
https://pubmed.ncbi.nlm.nih.gov/35279175/ | Article
2021
Ueno M, Zhang N, Hirata H, Barati D, Utsunomiya T, Shen H, Lin T, Maruyama M, Huang E, Yao Z, Wu JY, Zwingenberger S, Yang F, Goodman SB. Sex Differences in Mesenchymal Stem Cell Therapy With Gelatin-Based Microribbon Hydrogels in a Murine Long Bone Critical-Size Defect Model. Front Bioeng Biotechnol. 2021 Oct 19;9:755964. doi: 10.3389/fbioe.2021.755964. PMID: 34738008
https://pubmed.ncbi.nlm.nih.gov/34738008/ | Article
Ambrosi TH, Marecic O, McArdle A, Sinha R, Gulati GS, Tong X, Wang Y, Steininger HM, Hoover MY, Koepke LS, Murphy MP, Sokol J, Seo EY, Tevlin R, Lopez M, Brewer RE, Mascharak S, Lu L, Ajanaku O, Conley SD, Seita J, Morri M, Neff NF, Sahoo D, Yang F, Weissman IL, Longaker MT, Chan CKF. Aged skeletal stem cells generate an inflammatory degenerative niche. Nature. 2021 Sep; 597(7875):256-262. doi: 10.1038/s41586-021-03795-7. PMID: 34381212 https://pubmed.ncbi.nlm.nih.gov/34381212/ | Article
Liu E, Zhu D, Gonzalez Diaz E, Tong X, Yang F. Gradient Hydrogels for Optimizing Niche Cues to Enhance Cell-Based Cartilage Regeneration. Tissue Eng Part A. 2021 Jul;27(13-14):929-939. doi: 10.1089/ten.TEA.2020.0158. Epub 2020 Oct 19.
PMID: 32940136 https://pubmed.ncbi.nlm.nih.gov/32940136/ | Article
Zhu D, Trinh P, Li J, Grant GA, Yang F. Gradient hydrogels for screening stiffness effects on patient-derived glioblastoma xenograft cell fates in 3D. J Biomed Mater Res A. 2021 Jun;109(6):1027-1035. doi: 10.1002/jbm.a.37093. Epub 2020 Sep 21. PMID: 32862485.
https://pubmed.ncbi.nlm.nih.gov/32862485/ | Article
Wang C, Sinha S, Jiang X, Murphy L, Fitch S, Wilson C, Grant G, Yang F. Matrix Stiffness Modulates Patient-Derived Glioblastoma Cell Fates in Three-Dimensional Hydrogels. Tissue Eng Part A. 2021 Mar;27(5-6):390-401. doi: 10.1089/ten.TEA.2020.0110. Epub 2020 Nov 6. PMID: 32731804 https://pubmed.ncbi.nlm.nih.gov/32731804/ | Article
2020
Gegg C, Yang F*. “Spatially patterned microribbon-based hydrogels induce zonally-organized cartilage regeneration by stem cells in 3D”. Acta Biomaterialia 101, 196-205. | Article
Gegg C, Yang F*. “The Effects of ROCK Inhibition on Mesenchymal Stem Cell Chondrogenesis Are Culture Model Dependent”, Tissue Engineering Part A 26 (3-4), 130-139. | Article
Conrad B, Hayashi C, Yang F* . “Gelatin-based microribbon hydrogels support robust MSC osteogenesis across a broad range of stiffness”, ACS Biomaterials Science & Engineering, 2020 Apr, 6(6): 3454-3463; | Article
Barati D, Watkins K, Wang Z, Yang F* . “Injectable and Crosslinkable PLGA‐Based Microribbons as 3D Macroporous Stem Cell Niche”. Small, 2020 Jun; 16(22):e1905820. doi: 10.1002/smll.201905820. Epub 2020 Apr 27. PMID: 32338432 | Article
Ueno M, Utsunomiya T, Kohno Y, Maruyama M, Zhang N, Lin TD, Yao Z, Zwingenberger S, Yang F, Goodman SB. “Genetically modified IL-4 over- expressing MSCs enhance bone healing”, Cytotherapy, 22(5):S178, 2020 May, doi: 10.1016/j.jcyt.2020.03.372.| Article
Ueno M, Lo CW, Barati D, Conrad B, Lin TH, Kohno Y, Utsunomiya T, Zhang N, Maruyama M, Rhee C, Romero-Lopez M, Khan T, Tong X, Yao Z, Zwingenberger S, Yang F*, Goodman SB. “IL-4 overexpressing mesenchymal stem cells within gelatin-based microribbon hydrogels enhance Bone Healing in a Murine Long Bone Critical-size Defect Model”, Journal of Biomedical Materials Research: Part A. 2020 Nov 1; 108(11):2240-2250. doi: 10.1002/jbm.a.36982. PMID: 32363683 | Article
Barati D#, Gegg C#, Yang F*. "Nanoparticle-mediated TGF-β Release from Microribbon-based Hydrogels Accelerates Stem Cell-based Cartilage Formation in vivo", Annals of Biomedical Engineering 2020 Jul; 48 (7): 1971-1981. doi: 10.1007/s10439-020-02522-z. Epub 2020 May 6. PMID: 32377980. #: Equal contribution. | Article
Tang Y, Tong X, Conrad B, Yang F*. "Injectable and in situ Crosslinkable Gelatin Microribbon Hydrogels for Stem Cell Delivery and Bone Regeneration in vivo".Theranostics, 2020 May; 10(13): 6035–6047. doi: 10.7150/thno.41096, PMID: 32483436. | Article
Gegg C, Tong X, , Yang F*. “Mixed composition microribbon hydrogels induce rapid and synergistic cartilage regeneration by MSCs in 3D via paracrine signal exchange”. ACS Biomaterials Science & Engineering, 2020 May, doi: 10.1021/acsbiomaterials.0c00131 | Article
Wang C, Sinha S, Jiang X, Murphy L, Fitch S, Wilson C, Grant G, Yang F*. “Matrix stiffness modulates patient-derived glioblastoma cell fates in 3D hydrogels”, Tissue Engineering Part A,2020 July, DOI: 10.1089/ten.TEA.2020.0110. PMID: 32731804
| Article
Murphy M, Koepke LS, Lopez MT, Tong X, Ambrosi TH, Gulati GS, Marecic O, Wang Y, Ransom RC, Hoover MY, Steininger H, Zhao LM, Walkiewicz MP, Quarto N, Levi B, Wan D, Weissman IL, Goodman SB, Yang F, Longer MT, Chan CK. "Articular cartilage regeneration by activated skeletal stem cells". Nature Medicine, 2020 Aug 17, doi: 10.1038/s41591-020-1013-2. PMID: 32807933.
| Article
Zhu D, Trinh P, Li J, Grant GA, Yang F*. “Gradient hydrogels for screening stiffness effects on patient-derived glioblastoma xenograft cell fates in 3D”, J Biomed Mater Res A, 2020 Aug 30. Doi: 10.1002/jbm.a.37093. PMID: 32862485. Online ahead of print. | Article
Wang C, Sinha S, Jiang X, Fitch S, Wilson C, Caretti V, Ponnuswami A, Monje M, Grant G, Yang F*. “A comparable study of brain tumor cells from different age and anatomical locations using 3D biomimetic hydrogels”, Acta Biomater, 2020 Sep 7;S1742-7061(20)30521-3. doi: 10.1016/j.actbio.2020.09.007. PMID: 32911104. | Article
2019
Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A,McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M,Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC. “A Premature TerminationCodon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via ChronicActivation of Nonsense-Mediated Decay.” Circulation. 2019 Feb 5;139(6):799-811.doi: 10.1161/CIRCULATIONAHA.118.034624. PMID:30586709. | Article
Stanton AE, Tong X, Lee S, Yang F*. “Biochemical Ligand Density Regulates Yes-Associated Protein Translocation in Stem Cells through Cytoskeletal Tension andIntegrins”. ACS Appl. Mater. Interfaces 2019, 11, 9, 8849-8857. 2019 Feb 21, doi: 10.1021/acsami.8b21270 | Article
Rogan H, Ilagan F, Yang F*. “Comparing Single Cell Versus Pellet Encapsulationof Mesenchymal Stem Cells in Three-Dimensional Hydrogels for Cartilageregeneration."Tissue Eng Part A. 2019 May 2. doi: 10.1089/ten.TEA.2018.0289.[Epub ahead of print] PMID: 30672386 | Article
Lee S, Stanton AE, Tong X, Yang F*. “Hydrogels with enhanced protein conjugationefficiency reveal stiffness-induced YAP localization in stem cells depends onbiochemical cues.” Biomaterials. 2019 May;202:26-34. doi: 10.1016/j.biomaterials.2019.02.021. Epub 2019 Feb 23. PMID: 30826537 | Article
Wang C, Li J, Sinha S, Peterson A, Grant GA, Yang F*. “Mimicking brain tumor-vasculature microanatomical architecture via co-culture of brain tumor andendothelial cells in 3D hydrogels.” Biomaterials. 2019 May; 202:35-44. doi:10.1016/j.biomaterials.2019.02.024. Epub 2019 Feb 27. PMID: 30836243 | Article
Lin T, Kohno Y, Huang JF, Romero-Lopez M, Maruyama M, Ueno M, Pajarinen J,Nathan K, Yao Z, Yang F, Wu JY, Goodman SB. “Preconditioned or IL4-SecretingMesenchymal Stem Cells Enhanced Osteogenesis at Different Stages.” TissueEng Part A. 2019 Aug;25(15-16):1096-1103. doi: 10.1089/ten.TEA.2018.0292. Epub 2019 Mar 27. PMID: 30652628 | Article
Stanton AE, Tong X, Yang F*. “Extracellular matrix type modulates mechanotransduction of stem cells” Acta Biomater. 2019 Sep 15;96:310-320. doi: 10.1016/j.actbio.2019.06.048. Epub 2019 Jun 28. PMID: 31255664. | Article
Rogan H, Yang F*. “Optimizing 3D Co-culture Models to Enhance Synergy BetweenAdipose-Derived Stem Cells and Chondrocytes for Cartilage Tissue Regeneration”.Regenerative Engineering and Translational Medicine, 2019 Sep, 5:3, pp270-279. | Article
Stanton AE, Tong X, Yang F*. “Varying solvent type modulates collagen coatingand stem cell mechanotransduction on hydrogel substrates”. APLBioengineering. 2019 Sep 30;3(3):036108. doi: 10.1063/1.5111762. eCollection2019 Sep. PMID: 31592041 | Article
Conrad B, Hayashi C, Yang F*. “Gelatin-based microribbon hydrogels guidedmesenchymal stem cells to undergo endochondral ossification in vivo with bone-mimicking mechanical strength”. Regenerative Engineering and TranslationalMedicine, Published Dec 10 2019, https://doi.org/10.1007/s40883-019-00138-x | Article
Rogan H, Ilagan F, Tong X, Chu CR, Yang F*. “Microribbon-hydrogel compositescaffold accelerates cartilage regeneration in vivo with enhanced mechanicalproperties using mixed stem cells and chondrocytes”. Biomaterials. 2020Jan;228:119579. doi: 10.1016/j.biomaterials.2019.119579. Epub 2019 Oct31.PMID: 31698227 | Article
Gegg C, Yang F*. “Spatially patterned microribbon-based hydrogels induce zonally-organized cartilage regeneration by stem cells in 3D”. Acta Biomater. 2020 Jan 1;101:196-205. doi: 10.1016/j.actbio.2019.10.025. Epub 2019 Oct 19. PMID: 31634627. | Article
Gegg C, Yang F*. "The Effects of ROCK Inhibition on Mesenchymal Stem CellChondrogenesis Are Culture Model Dependent." Tissue Eng Part A. 2020Feb;26(3-4):130-139. doi: 10.1089/ten.TEA.2019.0068. Epub 2019 Sep 20. PMID:31411113. | Article
González Díaz EC, Sinha S, Avedian RS, Yang F*. "Tissue-engineered 3D models forelucidating primary and metastatic bone cancer progression." Acta Biomater. 2019Nov;99:18-32. doi: 10.1016/j.actbio.2019.08.020. Epub 2019 Aug 13. Review. PMID:31419564. | Article
2018
Zhu D, Tong X, Trinh P, Yang F*."Mimicking cartilage tissue zonal organization by engineering tissue-scale gradient hydrogels as 3D cell niche". Tissue Eng Part A. 2018 Jan;24(1-2):1-10. doi: 10.1089/ten.TEA.2016.0453. Epub 2017 Aug 22. | Article
Wang T, Yang F*."A comparative study of chondroitin sulfate and heparin sulfate for directing chondrogenesis of mesenchymal stem cells in 3D". Stem Cell Res Ther, 2017 Dec 19;8(1):284. doi: 10.1186/s13287-017-0728-6. | Article
Jiang X, Wang C, Fitch S, Yang F*."Targeting tumor hypoxia using nanoparticle-engineered CXCR4-overexpressing adipose-derived stem cells" Theranostics. 2018 Feb 2;8(5):1350-1360. doi: 10.7150/thno.22736. eCollection 2018. | Article
Conrad B, Han L, Yang F*."Gelatin-based microribbon hydrogels accelerate cartilage formation by mesenchymal stem cells in 3D", Tissue Engineering Part A , 2018 Jun 21. doi: 10.1089/ten.TEA.2018.0011. | Article
Zhu D,Trinh P, Liu E, Yang F*."Biochemical and Mechanical Gradients Synergize to Enhance Cartilage Zonal Organization in 3D". ACS Biomaterials Science & Engineering. August 2018, DOI: 10.1021/acsbiomaterials.8b00775. | Article
Tong, X., Yang F*. "Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration", Advanced Healthcare Materials, 2018 Apr;7(7):e1701065. doi: 10.1002/adhm.201701065. Epub 2017 Dec 27. | Article
2017
Tevlin R, Seo E, Marecic O, McArdle A, Tong X, Zimdahl B, Malkovskiy A, Sinha R, Gulati G, Li X, Wearda T, Morganti R, Lopez M, Ransom RC, Duldulao CR, Rodrigues M., Nguyen A, Januszyk M, Maan Z, Paik K, Yapa KS, Rajadas J, Wan DC, Gurtner GC, Snyder M, Beachy PA, Yang F, Goodman SB, Weissman IL, Chan C, Longaker MT. "Pharmacological rescue of diabetic skeletal stem cell niches". Science Translational Medicine 2017 Jan 11;9(372). pii: eaag2809. doi: 10.1126/scitranslmed.aag2809. PMID:28077677. | Article
Nabeshima A, Pajarinen J, Lin TH, Jiang X, Gibon E, Cordova LA, Loi F, Lu L, Jamsen E, Egashira K, Yang F, Yao Z, Goodman SB. "Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model", Radiology, 2017 Feb;117:1-9. doi: 10.1016/j.biomaterials.2016.11.039. Epub 2016 Nov 24. | Article
Zhu D#, Wang H#, Trinh P, Heilshorn S*, Yang F*."Elastin-like protein-hyaluronic acid (ELP-HA) hydrogels with decoupled mechanical and biochemical cues for cartilage regeneration". (*:co-first authors, # : co-corresponding author). Biomaterials, 2017 May;127:132-140. doi: 10.1016/j.biomaterials.2017.02.010. Epub 2017 Mar 3. PMID: 28268018. (#: co-first authors, *: Co-corresponding authors). | Article
Wang H, Zhu D, Paul A, Cai L, Enejder A, Yang F, Heilshorn S. "Covalently adaptable elastin-like protein – hyaluronic acid (ELP – HA) hybrid hydrogels with secondary thermoresponsive crosslinking for injectable stem cell delivery". Adv. Funct. Mater. 2017 May 19; 27, 1605609. | Article
Serpooshan V, Chen P, Wu H, Lee S, Sharma A, Hu D, Venkatraman S, Ganesan AV, Yang F, Wu JC, Demirci U, Wu SM. "Bioacoustic-enabled assembly of human iPSC-derived cardiomyocytes into 3D cardiac tissue". Biomaterials, 2017 Jul;131:47-57. doi: 10.1016/j.biomaterials.2017.03.037. Epub 2017 Mar 28. PMID: 28376365. | Article
Lee S#, Serpooshan V#, Tong X, Venkatraman S, Lee M, Wu SM*, Yang F*."Contractile force generation by 3D hiPSC-derived cardiac tissue is enhanced by rapid establishment of cellular interconnection in matrix with muscle-mimicking stiffness". (#:co-first authors, * : co-corresponding author). Biomaterials, 2017 Jul;131:111-120. doi: 10.1016/j.biomaterials.2017.03.039. Epub 2017 Mar 30. PMID: 28384492. | Article
Daldrup-Link HE, Chan C, Lenkov O, Taghavigarmestani S, Nazekati T, Nejadnik H, Chapelin F, Khurana A, Tong X, Yang F, Pisani L, Longaker M, Gambhir SS. "Detection of stem cell transplant rejection with ferumoxytol-MR Imaging: Correlation of MRI findings with intravital microscopy", Radiology, 2017 Aug;284(2):495-507. doi: 10.1148/radiol.2017161139. Epub 2017 Jan 27. PMID: 28128708. | Article
2016
Lee S, Tong X, Yang F*. "Effect of poly(ethylene glycol) hydrogel crosslinking mechanism on protein release." Biomaterials Science. 2016,4, 405-411, DOI: 10.1039/C5BM00256G, Epub 2015 Nov 5. | Article
Lee S, Tong X, Han LH, Behn A, Yang F*. "Aligned microribbon-like hydrogels for guiding three-dimensional smooth muscle regeneration" Journal of Biomedical Materials Research: Part A. 2016 May;104(5):1064-71. doi: 10.1002/jbm.a.35662. Epub 2016 Feb 14. | Article
Tong X, Jiang J, Zhu D, Yang F*. "Hydrogels with dual gradients of mechanical and biochemical cues for deciphering cell-niche interactions". ACS Biomaterials Science & Engineering. 2016, 2 (5), pp 845–852, DOI: 10.1021/acsbiomaterials.6b00074, Epub March 16, 2016. | Article
Deveza L, Choi J, Lee J, Huang N, Cooke J, Yang F*. "Polymer-DNA nanoparticle induced CXCR4 overexpression improves stem cell engraftment and tissue regeneration in a mouse hindlimb ischemia model." Theranostics, 2016 May 23;6(8):1176-89. doi: 10.7150/thno.12866. eCollection 2016. | Article
Han LH, Chung MT, Deveza L, Jiang X, Conrad B, Wang A, Butte MJ, Longaker MT, Wan D, Yang F*. "Microribbon-based hydrogels accelerate stem cell-based bone regeneration in a mouse critical-size cranial defect model". J Biomed Mater Res A. 2016 Jun;104(6):1321-31. doi: 10.1002/jbm.a.35715. Epub 2016 Apr 9. | Article
Keeney M*, Chuang MT*,Paik KJ, McArdle A, Morrison SD, Ransom C, Barbhaiya N, Zielins ER, Atashroo D, Jacobson G, Zare RN, Longaker MT, Wan DC, Yang F*, "Scaffold-mediated BMP-2 minicircle DNA delivery accelerated bone repair in a mouse critical-size calvarial defect model" (*: co-first authors, #: co-corresponding authors). J Biomed Mater Res A. 2016 Aug;104(8):2099-107. doi: 10.1002/jbm.a.35735. Epub 2016 Jun 3. (Epub ahead of print). (*: co-first authors, #: co-corresponding authors). | Article
Sato T, Pajarinen J, Behn A, Jang X, Lin T, Loi F, Yao Z, Egashira K, Yang F, Goodman SB. "The Effect of Local IL-4 Delivery or CCL2 Blockade on Implant Fixation and Bone Structural Properties in a Mouse Model of Wear Particle Induced Osteolysis". J Biomed Mater Res A. 2016 Sep;104(9):2255-62. doi: 10.1002/jbm.a.35759. Epub 2016 May 10. | Article
Tong X, Yang F*. "Sliding hydrogels with mobile molecular ligands and crosslinks as 3D stem cell niche", Advanced Materials, 2016 Sep;28(33):7257-63. doi: 10.1002/adma.201601484. Epub 2016 Jun 15. | Article
Wang C, Tong X, Jiang X, Yang F*. "The effect of matrix metalloproteinase-mediated matrix degradation on glioblastoma cell behavior in 3D PEG-based hydrogels". Journal of Biomedical Materials Research Part A, 2017 Mar;105(3):770-778. doi: 10.1002/jbm.a.35947. Epub 2016 Nov 18. | Article
Jiang X, Fitch S, Wang C, Wilson C, Li JF, Song B, Grant G, Yang F*. "Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery", Proc Natl Acad Sci USA, 2016 Nov 29;113(48):13857-13862. Epub 2016 Nov 14. | Article
Wang T, Lai JH, Han LH, Tong X, Yang F*. "Modulating stem cell-chondrocyte interactions for cartilage repair using combinatorial extracellular matrix-containing hydrogels". J. Mater. Chem. B, 2016 Nov; 4, 7641-7650. DOI: 10.1039/C6TB01583B. | Article
Wang T, Lai JH, Yang F*. "Effects of hydrogel stiffness and extracellular compositions on modulating cartilage regeneration by mixed populations of stem cells and chondrocytes in vivo", Tissue Engineering Part A, 2016 Dec;22(23-24):1348-1356 | Article
2015
Smeriglio P#, Lai JH#, Dhulipala L, Behn AW, Goodman SB, Smith RL, Maloney WJ , Yang F* and Bhutani N*. "Comparative Potential of Juvenile and Adult Human Articular Chondrocytes for Cartilage Tissue Formation in 3D Biomimetic Hydrogels" (#: equal contribution, *: co-corresponding authors). Tissue Eng Part A. 2015 Jan;21(1-2):147-55. doi: 10.1089/ten.TEA. 2014.0070. Epub 2014 Oct 1 | Article
Smeriglio P, Dhulipala L, Lai JH, Goodman SB, Dragoo JL, Smith RL, Maloney WJ, Yang F*#, and Bhutani N. "Collagen VI enhances Cartilage tissue generation by stimulating Chondrocyte proliferation" Tissue Eng Part A. 2015 Feb;21(3-4):840-9. doi:10.1089/ten.TEA.2014. 0375. Epub 2014 Nov 11. | Article
Lai JH, Kajiyama G, Smith RL, Maloney W, Goodman SB, Yang F*. "Interactions between Osteoarthritic Chondrocytes and Adipose-Derived Stem Cells is Dependent upon Cell Distribution in in three-dimension and transforming growth factor-β3 induction" Tissue Eng Part A. 2015 Mar;21(5-6):992-1002. doi: 10.1089/ten.TEA.2014.0244. Epub 2015 Feb 6. | Article
Nejadnik H, Diecke S, Lenkov OD, Chapelin F, Donig J, Tong X, Derugin N, Chan RC, Gaur A, Yang F, Wu JC, Daldrup-Link HE. "Improved approach for chondrogenic differentiation of human induced pluripotent stem cells." Stem Cell Rev. 2015 Apr;11(2):242-53. doi: 10.1007/s12015-014-9581-5. | Article
Deveza L, Ashoken J, Casteneda G, Keeney M, Tong X, Han L, Yang F*. "Microfluidic Synthesis of Biodegradable Polyethylene-Glycol Microspheres for Controlled Delivery of Proteins and DNA Nanoparticles" ACS Biomater. Sci. Eng., 2015, 1 (3), pp 157–165. DOI: 10.1021/ab500051v. Epub Feb 10, 2015. | Article
Lee J, Taylor SE, Smeriglio P, Lai J, Maloney WJ, Yang F, Bhutani N. "Early induction of a prechondrogenic population allows efficient generation of stable chondrocytes from human induced pluripotent stem cells". FASEB J. 2015 Apr 24. pii: fj.14-269720. [Epub ahead of print] | Article
Jiang X, Taishi S, Yao ZY, Keeney M, Pajarinen J, Lin TH, Loi F, Egashira K, Goodman S, Yang F*. "Local delivery of mutant CCL2 protein reduced orthopaedic implant wear particle-induced osteolysis and inflammation in vivo." Journal of Orthopaedic Research 2016 Jan;34(1):58-64. doi: 10.1002/jor.22977. Epub 2015 Jul 29. | Article
Tong X, Lee S, Bararpour L, Yang F*. "Long-term controlled protein release from poly(ethylene glycol) hydrogels by modulating mesh size and degradation." Macromolecular Biosciences. 2015 Dec;15(12):1679-86. doi: 10.1002/mabi.201500245. Epub 2015 Aug 11. | Article
Smeriglio P, Lai JH, Yang F, Bhutani N. "3D hydrogel scaffolds for articular chondrocyte culture and cartilage generation." J Vis Exp. 2015 Oct 7;(104). doi: 10.3791/53085. | Article
Keeney M, Yammane M, Lee M, Yang F*. "Nanocoating for biomolecule delivery using layer-by-layer self-assembly." Journal of Materials Chemistry B, 2015 Sep, 3, 8757-8770. | Article
2014
Han LH, Tong X, Yang F*. "Photocrosslinkable PEG-based Microribbons for Forming 3D Macroporous Scaffolds with Decoupled Niche Properties". Advanced Materials, 2014 Mar 19, 26 (11):1757-1762. Epub 2013 Dec 17, DOI: 10.1002/adma.201304805. | Article
Hammer J#, Han LH#, Tong X, Yang F*. "A Cell-friendly Process to Fabricate Hydrogels with Microchannel-like Porosity for Tissue Engineering." Tissue Engineering, Part C Methods. 2014 Feb;20(2):169-76. doi: 10.1089/ten.TEC.2013.0176. Epub 2013 Jul 17. (#: Equal contribution) | Article
Tong X, Yang F*. "Engineering Interpenetrating Network Hydrogel as Biomimetic Cell Niche with Independently Tunable Biochemical and Mechanical Properties." Biomaterials 2014 Feb;35(6):1807-15. doi: 10.1016/j.biomaterials.2013.11.064. Epub 2013 Dec 9. | Article
Wang C, Tong X, Yang F*. "Bioengineered 3D Brain Tumor Model to Elucidate the Effects of Matrix Stiffness on Glioblastoma Cell Behavior using PEG-based Hydrogels" Molecular Pharmaceutics, 2014 Jul 7;11(7):2115-25. doi: 10.1021/mp5000828. Epub 2014 Apr 29. | Article
Wang TY, Lai JH, Han LH, Tong X, Yang F*. "Chondrogenic differentiation of adipose-derived stromal cells in Combinatorial Hydrogels Containing Cartilage Matrix Proteins with Decoupled Mechanical Stiffness". Tissue Engineering Part A, 2014 Aug;20(15-16):2131-2139. Epub 2014 Apr 7. doi:10.1089/ten.tea.2013.0531. | Article
Lin TH, Yao Z, Sato T, Keeney M, Li C, Pajarinen J, Yang F, Egashira K, Goodman SB, "Suppression of wear particle induced pro-inflammatory cytokine and chemokine production in macrophages via NF-kappa B decoy oligodeoxynucleotide: A preliminary report". Acta Biomaterialia, 2014 Aug;10(8):3747-55. doi: 10.1016/j.actbio.2014.04.034. Epub 2014 May 9. | Article
Yao Z, Keeney M, Lin T, Barcay K, Water H, Pajarinen J, Egashira K, Yang F*, Goodman S. "Mutant MCP-1 protein attenuates migration of and inflammatory cytokine release by macrophages exposed to orthopaedic implant wear particles". J Biomed Mater Res A 2014 Sep;102(9):3291-7. doi: 10.1002/jbm.a.34981. Epub 2013 Nov 20. | Article
Madl C, Keeney M, Li X, Han LH, Yang F*. "Co-release of cells and polymeric nanoparticles from sacrificial microfibers enhances non-viral gene delivery inside 3D hydrogels." Tissue Engineering Part C Methods, 2014 Oct;20(10):798-805. doi: 10.1089/ten.TEC.2013.0669. Epub 2014 Apr 4. | Article
Lee S, Tong X, Yang F*. "The Effects of Varying Poly(ethylene glycol) Hydrogel Crosslinking Density and Crosslinking Mechanism on Protein Accumulation in Three-dimensional Hydrogels" Acta Biomaterialia, 2014 Oct;10(10):4167-74. doi: 10.1016/j.actbio.2014.05.023. Epub 2014 Jun 2. | Article
Goodman SB, Gibon E, Pajarinen J, Lin TH, Keeney M, Ren PG, Nich C, Rao A, Yao Z, Egashira K, Yang F, Konttinen YT. "Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement". Journal of the Royal Society Interface, 2014 Jan 29;11(93):20130962. doi: 10.1098/rsif.2013.0962. Print 2014 Apr 6.
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2013
Deveza L, Choi J, Imanbayev G, Yang F*. "Paracrine Release from Non-viral Engineered Adipose Derived Stromal Cells Promotes Endoethelial Cell Survival and Migration in vitro", Stem Cells and Development, 2013 Feb 1;22(3):483-91. Epub 2012 Aug 13. | Article
Nauta A, Seidel C, Deveza L, Montoro D, Grova M, Ko SH, Hyun J, Gurtner G, Longaker MT, Yang F*. "Adipose Derived Stromal Cells Overexpressing Vascular Endothelial Growth Factor Accelerate Wound Closure in a Mouse Excisional Wound Healing Model", Molecular Therapy, 2013 Feb;21(2):445-55. Epub 2012 Nov 20. | Article
Han LH, Yu S, Wang TY, Behn AW, Yang F*. "Microribbon-like Elastomers for Fabricating Macroporous and Highly Flexible Scaffolds that Support Cell Proliferation in 3D", Advanced Functional Materials, 2013 Jan; 23:346–358. Epub 2012 Sep 4. (Highlighted as journal cover image) | Article
Nii M, Lai J, Keeney M, Han LH, Behn A, Imanbayev G, Yang F*. "The effects of Interactive Mechanical and Biochemical Niche Signaling on Osteogenic Differentiation of Adipose-derived Stem Cells Using Combinatorial Hydrogels", Acta Biomaterialia, 2013 Mar;9(3):5475-83. Epub 2012 Nov 12. | Article
Chung MT, Liu CJ, Hyun JS, Lo DD, Montoro DT, Hasegawa M, Li S, Sorkin M, Rennert R, Keeney M, Yang F, Quarto N, Longaker M, Wan DC. "CD90 (Thy-1) Positive Selection Enhances Osteogenic Capacity of Human Adipose-Derived Stromal Cells." Tissue Engineering Part A. 2013 Apr;19(7-8):989-97. Epub 2013 Jan 28. | Article
Keeney M, Mathur M, Cheng E, Yang F*. "The Effects of Polymer End-group Chemistry and Order of Deposition on Controlled Protein Delivery from Layer-by-layer Assembly", Biomacromolecules, 2013, 14 (3): 794–800. Epub 2013 Jan 29. | Article
Ramasubramanian A#, Jeeawoody S#, Yang F*. "Gene Delivery of Osteoinductive Signals to a Human Fetal Osteoblast Cell Line Induces Apoptosis in a Dose-Dependent Manner". Drug Delivery and Translational Research. 2013 July 13 Epub ahead of print (#: equal contribution). | Article
Keeney M#, Ong SG#, Padilla A, Yao Z, Goodman S, Wu J, Yang F*. "Development of Poly (β-amino esters)-Based Biodegradable Nanoparticles for Non-viral Delivery of Minicircle DNA." ACS Nano., 2013, 7 (8), pp 7241-7250. Epub July 9, 2013 (#: equal contribution). | Article
Keeney M, Onyiah S, Zhang Z, Tong X, Han LH, Yang F*. "Modulating Polymer Chemistry to Enhance Non-viral Gene Delivery inside Hydrogels with Tunable Matrix Stiffness". Biomaterials. 2013 Dec;34(37):9657-65. doi: 10.1016/j.biomaterials.2013.08.050. Epub 2013 Sep 5. | Article
Keeney M#, Deveza L#, Yang F*. "Programming Stem Cells for Therapeutic Angiogenesis using Biodegradable Polymeric Nanoparticles". The Journal of Visualized Experiment. 2013 Sep 27;(79):e50736. doi: 10.3791/50736. (#: equal contribution.) | Article
Keeney M, Waters H, Barcay K, Jiang XY, Yao Z, Pajarinen J, Egashira K, Goodman S, Yang F*. "Mutant MCP-1 Protein Delivery from Layer-by-Layer Coatings on Orthopaedic Implants to Modulate Inflammatory Response". Biomaterials. 2013 Dec;34(38):10287-95. doi: 10.1016/j.biomaterials.2013.09.028. Epub Sep 26. 2013. | Article
Lai JH, Kajiyama G, Smith RL, Maloney W,Yang F*.“Stem cells catalyze cartilage formation by neonatal chondrocytes in 3D biomimetic hydrogels”. Scientific Reports 3, Article number: 3553 (2013) doi:10.1038/srep03553 | Article
Goodman S, Yao Z, Keeney M, Yang F*. "The Future of Biologic Coatings for Orthopaedic Implants", Biomaterials, 2013 Apr; 34(13):3174-83. Epub 2013 Feb 4. | Article
Yang F*, Goldberg M, Langer R, Anderson DG. "Development of Biomaterials for Delivery of Nucleic Acid Therapeutics", Modern Biopharmaceuticals. (in press) | Article
2012
Cho SW#, Yang F#, Son SM, Park HJ, Green JJ, Bogatyrev S, Mei Y, Park S, Langer R, Ander DG. "Therapeutic Angiogenesis using genetically engineered human endothelial cells." ,J. of Conrolled Release 2012 Jun 28;160(3):515-24. Epub 2012 Mar 15. (#: equal contribution). | Article
Deveza L, Choi J, Yang F*. "Therapeutic Angiogenesis for Treating Cardiovascular Diseases." Theranostcis. 2012;2(8):801-14. Epub 2012 Aug 16. | Article
Park HJ, Yang F*, Cho SW. "Nonviral Delivery of Genetic Medicine for Therapeutic Angiogenesis." Advanced Drug Delivery Review. 2012 Jan; 64(1):40-52. Epub 2011 Sep 24. | Article
Lai JH, Ramasubranian A, Jeeawoody S, Yang F*. "Nanomaterials for Engineering Cell Microenvironment and Gene delivery." Tissue Engineering and Regenerative Medicine: A Nano Approach, CRC Press, 2012. | Article
2011
Ramasubramanian A, Shiigi S, Lee GK, Yang F*. "Non-viral delivery of indutive and suppressive signals to adipose-derived stem cells for osteogenic differentiation." Pharm Res. 2011 Jun;28(6):1328-37. Epub 2011 Mar 19. | Article
Mass M, Guo P, Keeney M, Yang F*, Hsu TM, Fuller GG, Martin CR, Zare RN. "Bio-inspired mineralized nanofibers prepared by nanoporous membranes.", Nano Lett. 2011 Mar 9;11(3):1383-8. Epub 2011 Jan 31. | Article
Keeney M, Han LH, Onyiah S, Yang F*. "Tissue Engineering: Focus on musculoskeletal system." Biomaterials Science-an integrated clinical and engineering approach. CRC Press, 2012.
Keeney M, Lai J, Yang F*. "Recent Progress in Cartilage Tissue Engineering." Curr Opin Biotechnol. 2011 Oct; 22(5):734-40. Epub 2011 Apr 29. | Article
Before Joining Stanford
Wang DA, Williams CG, Yang F , Elisseeff JH, “Enhancing the Tissue-Biomaterial Interface: Tissue initiated Integration of Biomaterials", Advanced Functional Materials, 2004 Dec 14(12): 1152-1159. | Article
Wang DA, Williams CG, Yang F, Cher N, Lee H, Elisseeff JH, "Bioresponsive Phosphoester Hydrogels for Bone Tissue Engineering", Tissue Engineering, 2005 Jan-Feb;11(1-2):201-213. | Article
Yang F , Williams CG, Wang DA, Lee H, Manson P, Elisseeff JH, “The effect of incorporating RGD adhesive peptide in polyethylene glycol diacrylate hydrogel on osteogenesis of bone marrow stromal cells”. Biomaterials, 2005 Oct;26(30):5991- 5998. | Article
Wang YL, Xiao R, Yang F, Karim BO, Iacovelli AJ, Cai JL, Lerner CP, Richtsmeier JT, Leszl JM, Hill CA, Yu K, Ornitz DM, Elisseeff JH, Huso DL, Jabs EW, “Abnormalities in Cartilage and Bone Development in the Apert Syndrome FGFR2(+/S252W) Mouse”, Development. 2005 Aug; 132(15):3537-3548. | Article
Reyes J MG, Fermanian S., Yang F, Zhou SY, Herretes S, Murphy DB, Elisseeff JH, Chuck RS, “Metabolic Changes in Mesenchymal Stem Cells in Osteogenic Media Measured by autofluorescence Spectroscopy”, Stem Cells. 2006 May; 24(5):1213-1217. | Article
Yang F* , Wang YL, Zhang Z, Hsu Bryan, Jabs EW, Elisseeff JH, “The study of abnormal bone development in the Apert syndrome Fgfr2+/S252W mouse using a 3D hydrogel culture model”. Bone, 2008 Jul; 43(1):55-63. | Article
Yang F* , Mei Y, Langer R, Anderson DG. “High-throughput Optimization of Stem Cell Microenvironments”. Combinatorial Chemistry & High Throughput Screening. 2009 12(6), 544-553. | Article
Cho SW, Hartle L, Son SM, Yang F* , Goldberg M, Xu Q, Langer R, Anderson DG. “Delivery of Small Interfering RNA for Inhibition of Endothelial Cell Apoptosis by Hypoxia and Serum Deprivation”. Biochemical and Biophysical Communications 2008 Nov 7;376(1):158-63. | Article
Yang F, Green JJ, Dinio T, Keung L, Cho SW, Park H, Langer R, Anderson DG. “Gene Delivery to Human Adult and Embryonic cell-derived Stem Cells Using Biodegradable Nanoparticulate Polymeric Vectors”. Gene Therapy, 16(4), 533-546. 2009. | Article
Sunshine J, Green JJ, Mahon K, Yang F , Langer R, and Anderson DG. "Small Molecule End Group of Linear Polymer Determines Cell-type Gene Delivery Efficacy. " Advanced Materials 2009, 21: 1-5. | Article
Cho SW, Goldberg M, Son SM, Xu Q, Yang F, Mei Y, Bogatyrev S, Langer R, Anderson DG. "Lipid-like nanoparticles for small Interfering RNA delivery to endothelial Cells. " Advanced Functional Materials, 19 (19):3112-3118, 2009. | Article
Yang F#, Cho SW#, Son SM, Botatyrev S, Singh D, Green JJ, Mei Y, Park S, Bhang, SH, Kim BS, Langer R, Anderson DG. “Genetic engineering of human stem Cells for enhanced angiogenesis using biodegradable polymeric nanoparticles”. Proc Natl Acad Sci USA, 2010 Feb 23; 107(8):3317-22. Epub 2009 Oct 5 2009. (#: equal contribution) | Article
Yang F, Cho SW, Son SM, Hudson SP, Bogatyrev S, Keung L, Kohane DS, Langer R, Anderson DG. "Combinatorial Extracellular Matrices for Human Embryonic Stem Cell Differentiation in 3D.", Biomacromolecules. 2010 Aug 9;11(8):1909-14. Epub 2010 Jul 9. | Article
Abrahamsson C#, Yang F#, Park H, Brunger J, Valonen P, Langer R, Welter J, Caplan A, Guilak F, Freed L. "Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on 3D-woven scaffolds.", Tissue Engineering Part A. 2010 Dec;16(12):3709-18. Epub 2010 Sep 6. (#: equal contribution) | Article
Elisseeff J, Puleo C, Yang F, Sharma B, “Advances in Skeletal Tissue Engineering with Hydrogels”. Orthod Craniofac Res 2005 Aug; 8(3): 150-61. | Article
Yang F, Elisseeff JH, “Cartilage Tissue Engineering”. Biomedical Engineering Handbook, Tissue Engineering Section, (2006). | Article
Yang F, Neeley WL, Moore MJ, Karp JM, Shukla A, Langer R. “Tissue Engineering: The Therapeutic Strategy of the 21st Century”. Nanotechnology and Tissue Engineering. (2008) | Article